Fig. 6
From: ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics
Activation of the alternative pathway in arterioles in CADASIL. A-F, Representative images of C3d (A, B), Factor B (C, D) and C5-9 complex (E, F) immunostaining in the temporal white matter of Control (A, C, E) and CADASIL (B, D, F). Lack of C1q immunoreactivity in CADASIL, C3d (B) and Factor B (D) were upregulated, and C5-9 complex (F) was observed in vessels compare to control. Scale bars represents 100 μm (B, D, F)