Fig. 1
From: ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics
Cerebral arteriopathic changes in CADASIL. A-I, Representative images of arterioles in the deep WM showing differential degeneration of vessel walls. A-C, H, Sections stained with: H&E (A), LFB (B), PAS (C) and Perl’s (H) stain. D-G, I, Adjacent sections immunostained with antibodies to COL4 (D), αSMA (E), medin (F), N3ECD (G) and ubiquitin (I). Immunostaining with antibodies to fractin and amyloid P component was similar to medin (not shown). Note the differential changes in VSMCs and localization of N3ECD within intimal layers in the markedly hyalinised vessel (G). Perl’s stain (H) reveals perivascular iron (hemosiderin) deposits. Scale bar represents 200 μm (A-I)