Fig. 6
From: Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Ganglioglioma-associated myeloid cells. A Myeloid supercluster feature plots of RNA concentrations (log1p, base 2) for key general myeloid (PTPRC, ITGAM, CD14), microglia (P2RY12, TYROBP, SALL1, SPI1), macrophage (CD44, SIGLEC1), classical proinflammatory (IL1A, TNF, CD40; no expression for IL6, so not shown), anti-inflammatory (IL10, TGFB1), tissue reparative M2 (CD163, MSR1, MRC1, CD68), and M1 proinflammatory (TLR2, CD86, HLA-DRA, NOS2) markers as well as C1QB and SPP1. B Microglia feature plot of cellular hierarchy by CellRank/CytoTRACE pseudotime. C Heatmap of microglia expression of transcripts encoding lymphocyte stimulatory and inhibitory ligands of interest a priori. D Hierarchy plots of CellChat results showing significant involvement of microglia in TGFB and CSF pathways. Lines weighted by interaction significance. E Most (top 10 or fewer if Bonferroni-adjusted-p-value > 0.05) activated or suppressed Wikipathways compared to the bulk ganglioglioma population for each of the microglial clusters