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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease

Fig. 6

Altered gene expression in the LC of htau +/- mice at 4 months. A Atlas plate indicating the LC region that was dissected for RT-qPCR analysis. B Metabolic pathway for norepinephrine and other metabolites of tyrosine showing biosynthetic and metabolic enzymes analyzed by RT-qPCR. RT-qPCR analysis of genes involved in C Norepinephrine biosynthesis and metabolism D Kynurenine pathway E Monoamine transporters F 5-HT signal transduction/receptors, G Inflammatory pathways H Protein phosphorylation and I Protein aggregation. J Heat map of gene expression for all genes analyzed. *p < 0.05, **p < 0.01

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Acta Neuropathologica Communications

ISSN: 2051-5960

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