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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease

Fig. 5

Dysregulation of gene expression in the DRN of htau +/- mice at 4 months. A Atlas plate indicating the DRN region that was dissected for RT-qPCR analysis. B Metabolic pathway for serotonin and other metabolites of tryptophan showing biosynthetic and metabolic enzymes analyzed by RT-qPCR. RT-qPCR analysis of genes involved in C Monoamine biosynthesis, reuptake and metabolism, D Kynurenine pathway, E Monoamine transporters, F 5-HT signal transduction/receptors, G Inflammatory pathways and H Protein phosphorylation and I Protein aggregation. J Heat map of gene expression for all genes analyzed. *p < 0.05, **p < 0.01

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Acta Neuropathologica Communications

ISSN: 2051-5960

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