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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease

Fig. 1

Htau mice exhibit depressive-like behaviors at 4 and 6 months of age. A Experimental timeline of behavioral studies in htau and C57BL/6J mice. Behavior of 4-month-old htau and C57BL/6J mice in the B, C EPM, D, E open field, F social interaction test, G sucrose preference test and H, I forced swim test. Behavior of 6-month-old htau and C57BL/6J mice in the J, K EZM, L, M open field, N social interaction test, O sucrose preference test, P forced swim test and Q Barnes maze. These results indicate depressive-like behaviors in htau mice relative to C57BL/6J mice. *p < 0.05, **p < 0.01, ****p < 0.0001

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Acta Neuropathologica Communications

ISSN: 2051-5960

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