Fig. 2

Lipid profiles distinguish FTD-GRN from FTD-C9orf72 and control cases. (A) PLS-DA scores plots for control (n = 11, orange), FTD-C9orf72 (n = 11, blue), and FTD-GRN (n = 6, yellow) cases for each brain region, based on the untargeted lipidomic data. Component % refers to the percentage of variance explained by each principal component. (B) Variable Importance in the Projection (VIP) scores for the 15 features that contribute most to separation of the groups in PLS-DA. ST: sulfatide, Hex1Cer: monohexosylceramide, Hex2Cer: dihexosylceramide, SM: sphingomyelin, CholE: cholesterol ester, PC: phosphatidylcholine, PE: phosphatidylethanolamine. (C,D) Levels of CholE species in (C) frontal and (D) parietal white matter. Horizontal bars show mean. Missing values indicate that the specific CholE was below the limit of detection in that sample. Sample groups were compared by one-way ANOVA adjusted for PMI and age, and p values were corrected for false discovery rate. Results of Tukey’s post-test are shown: *p < 0.05; **p < 0.01; ***p < 0.001. (E,F) Total cholesterol esters (CholE)/cholesterol (Chol) in (E) frontal and (F) parietal white matter