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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Tumor lineage-specific immune response in brain metastatic disease: opportunities for targeted immunotherapy regimen?

Fig. 4

Digital spatial profiling of BM-LUAD and BCBM. a IHC double staining by DSP for immune cell infiltration (CD163 + M2 macrophages and CD14 + monocytes) in BCBM and BM-LUAD. b IHC staining for the expression of therapeutic targets VISTA and IDO1 in BCBM and BM-LUAD. c Multicolor fluorescence localizing expression of VISTA in BM-LUAD. The grey arrow points to the expression of VISTA in tumor cells; the pink arrow points VISTA expression in microglial cells; the orange arrow points VISTA expression in immune cells (Yellow: TTF1 [Thyroid transcription factor], Aqua: CD3, Red: TMEM19 [Transmembrane Protein 19], White: VISTA, Green: PanCK)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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