Fig. 8

Visual IOS responses after zolpidem administration. a Experimental timeline. b Images and c quantification of IOS imaging in the visual cortex before and after zolpidem (n = 10, Zolp) or PBS injections, (n = 8) showing that Zolp treatment normalizes hemodynamic responses in CrT^−/y mice (two-way RM ANOVA, interaction time x treatment: p < 0.01, Sidak post-hoc multiple comparisons, p < 0.05 at post). Dashed line represents the average amplitude and grey area indicates the 95% confidence interval for WT mice, as previously measured [35]. The look-up-table is also shown. Scale bar: 1.8 mm. L, lateral; A, anterior. c Delta of pre-post injection amplitude (t-test, p < 0.01). *p < 0.05, **p < 0.01. Data are expressed as mean ± SEM. Circles represent single data values