Fig. 6

mGluR antagonism or ceftriaxone is sufficient to prevent short-term plasticity impairment in 3xTg mice. A Post-tetanic potentiation (PTP) in acute slices from WT (black) and 3xTg (orange) mice. PTP is induced by high-frequency stimulation (HFS) at time = 0. B PTP is significantly decreased in 3xTg mice. C Paired-pulse ratio (PPR) in WT and 3xTg. D PPR changes after HFS are impaired in 3xTg mice. E–H PTP and PPR responses to HFS in WT and 3xTg mice during bath application of MTEP (100 µM). I–L PTP and PPR responses to HFS in WT and 3xTg mice during bath application of MSOP (100 µM). M–P PTP and PPR responses to HFS in WT and 3xTg mice treated with ceftriaxone. Scale bars: 25 ms, 500 µV. Error bars indicate s.e.m. *p < 0.05, ** p < 0.01. ns, not significant