Fig. 4

DNA methylation patters remain stable upon recurrence. A Unsupervised hierarchical clustering analysis of the top 10 000 most variable CpG sites on the methylation array clusters the tumor samples from each patient together except for seven cases, represented in the figure with an asterisk (*). The tumor samples are color-coded by patient identity and tumor incidence. B Proportion of cases based on glioma subtypes from Ceccarelli et al. [7] (left). The G-CIMP-high/low signature of the tumors was mainly maintained during tumor progression (right). C Overall survival of patients based on the glioma subtypes. Significance: p-value < 0.05