Fig. 2
From: Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Proteomic analysis of inherited and sporadic late-onset nemaline myopathies after laser capture microdissection (A) Nemaline rod and rod-free areas from sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) samples were subjected to laser capture microdissection and subsequently processed for proteomic analysis. (B) Volcano plots demonstrate differentially expressed proteins between rod and rod-free areas, as well as between SLONM and iNM samples. The left panel depicts protein abundance in nemaline rod areas relative to rod-free areas across all samples, whereas the center and right panels depict protein abundance in SLONM relative to iNM in rod and rod-free areas, respectively. (C) Comparison of the rod areas of SLONM and iNM showed enrichment of targets corresponding to several immune, structural, metabolic, and cellular pathways