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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

Fig. 7

Microglial morphology was altered in SI/NB and hippocampus 12 m after jmTBI. A Increased microglial density in SI/NB after jmTBI (A2) compared to shams (A1). B Iba-1 staining (mean OD, as %sham) in the contralateral SI/NB were significantly increased in the jmTBI compared to the sham cohorts. Two-way ANOVA with Sidack post-hoc test. Data expressed as mean + SEM. *P > 0.05. C Individual microglia from sham (C1-3) and jmTBI (C4-6) and their respective tagged skeletons and isolated skeleton structures from the SI/NB D Quantification of microglial skeleton parameters revealed decreased branch length in the contralateral SI/NB of jmTBI mice. E Microglia from the CA1 and their respective tagged skeletons and isolated skeleton structures in the in sham (E1-3) and jmTBI (E4-6) mice. F Microglia from jmTBI mice have decreased branch length and endpoints in CA1, especially in the contralateral side. Two-way ANOVA (# indicating jmTBI vs sham overall in ipsi and contra) with Sidack post-hoc test (*indicating jmTBI vs sham differences within the ipsi or contra side). Data expressed as mean + SEM. * or #P < 0.05, ** or ##P < 0.01 G Illustration of skeleton analysis parameters (passed Shapiro–Wilk normality test)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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