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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

Fig. 2

DTI alterations are detected in the hippocampus and SI/NB 12 m after jmTBI. A Representative T2WI images of sham and jmTBI mouse brains at the coronal level of the SI/NB indicated on contralateral hemisphere. T2WI did not show gross morphology differences between sham and jmTBI. B Representative coronal pseudo-colored fractional ansiotropic (FA) images of sham and jmTBI mouse brains at the site of the impact (top panels) with expanded FA maps of the ipsilateral hippocampus (bottom panels). Arrowhead highlights altered FA within the corpus callosum and arrow indicate the CA1 region of the hippocampus. C FA was significantly decreased within the hippocampal DG but not CA1. D AD was significantly decreased in the ipsilateral but not contralateral SI/NB. C and D Two-way ANOVA (# indicating global jmTBI vs sham differences) with Sidack post-hoc test (* indicating jmTBI vs sham). Data expressed as mean + SEM. # or *P < 0.05

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Acta Neuropathologica Communications

ISSN: 2051-5960

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