Fig. 4

Increased spontaneous, p53-indepenedent CGNP apoptosis contributes to growth failure in Eed-deleted cerebella. A Heat map of BH3-only gene expression in each CGNP/CGN cluster. Hierarchical clustering based on BH3-only genes grouped together the CGNP clusters that were enriched in Eed^cKO mice (red box), and identified a set of apoptosis regulators (blue box) that was up-regulated in this group. B Heat map of BH3-only gene expression in the combined set of CGNP/CGN clusters, comparing Eed^cKO and control genotypes, with the blue box highlighting the same apoptosis regulators as in (A). C Representative H&E-stained sagittal sections of P21 WT, Eed^cKO, Eed/Trp53^dKO, and Eed/Bax/Bak^tKO mice. * indicates regions of IGL. Arrow indicates regions of persistent or absent EGL