Fig. 2

a Principal component analysis of SHH-MB gene expression primary-relapse dataset based on the top 500 most highly variable genes. Primary and relapse tumor profiles from the same patient connected via dot lines, target component variance percentage (VP) is shown in axis labels. b Association of transcriptome variance between primary and relapse SHH-MB with age of the patients. c Boxplot demonstrating the transcriptome variance between primary and relapse tumors among SHH-MB with (n = 11) and without (n = 13) novel CNVs. d Copy number profiles derived from methylation data of primary (top) and relapse (bottom) tumors from the same SHH-MB infant patient. e Boxplot demonstrating the transcriptome variance between primary and relapse MB SHH among relapse types (local: 12, metastatic: 4, combined: 8 cases)