Fig. 1

a Annotation onco-plot describing patient histological and molecular characteristics for target primary-relapse tumor pairs with available RNA sequencing data (n = 43). The following abbreviations were used: SHH_INF—infant SHH, CH_AD—child–adult SHH, DNMB—desmoplastic/nodular, LCA—large cell/anaplastic, PFS—progression-free survival, CNV—copy number variants. b Principal component analysis of full MB gene expression primary-relapse dataset based on the top 500 most highly variable genes. Tumor profiles from the same patient connected via dot lines, target component variance percentage (VP) is shown in axis labels. c Boxplot demonstrating the transcriptome variance between primary and relapse tumors among MB groups (SHH-MB—24, Group 3 MB—5, Group 4 MB—14 cases)