Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology

Table 1 Demographic, clinical, and post-mortem characterisitcs of selected semantic dementia patients and non-demented controls

Case type	Sample number	Sex	Age at death	Disease duration (yrs)	Post mortem delay (min)	Braak stage	Thal stage	Batch number
Semantic dementia	SD02	M	62	14	280	0	0	2
	SD04*	F	65	20	330	0	0	3
	SD05	M	66	10	320	0	0	3
	SD07	F	64	11	385	0	0	2
	SD08	M	69	12	320	0	0	1
	SD09	F	74	11	240	1	0	1
	SD10	M	68	13	420	1	3	1
	SD11	M	66	15	345	1	0	2
	SD12	F	72	12	375	2	2	1
	SD13	F	72	9	250	3	2	4
	SD14	M	72	15	455	2	1	4
	SD16	M	74	13	225	0	1	2
	SD17	F	67	9	275	2	1	3
	SD18	F	68	16	225	0	0	3
	SD19	M	61	12	290	0	0	4
n = 15	Average		68	13	316
Controls	NDC1	M	64		505	1	1	1
	NDC2	M	75		430	1	1	1
	NDC3	F	57		460	0	0	1
	NDC4	F	90		350	2	0	1
	NDC5	F	69		510	1	0	2
	NDC-6	F	54		335	0	0	2
	NDC-7	M	70		1245	1	0	2
	NDC8	F	68		630	2	1	2
	NDC9*	F	74		360	0	0	3
	NDC10*	M	69		325	1	1	3
	NDC11	F	92		265	3	1	3
	NDC12	M	79		345	2	1	3
	NDC13	F	79		840	3	2	4
	NDC14	F	67		790	0	0	4
	NDC15	M	56		300	3	2	4
	NDC16	F	75		550	1	1	4
	NDC17	M	71		345	1	2	4
n = 17	Average		71	NA	505

For the mass spectrometry, samples were split in four batches of each 3–5 patient and control samples. All patients were characterized by FTLD-TDP type C neuropathology
SD semantic dementia, NDC non-demented control
*Three samples from batch 3 (one patient and two control samples) were excluded from differential abundance analysis following quality control, indicating these samples as outliers. Note that the samples partially overlap with those reported in a previous publication on somatic mutations in semantic dementia[8]

ISSN: 2051-5960