Fig. 2

Proteins with differential abundance in SD patients compared to non-demented controls. Fold-changes (x-axis) were determined and P-values (y-axis) adjusted for multiple testing using the FDR approach (Benjamini–Hochberg procedure). Proteins with differential abundance in SD were defined by adjusted P-value < 0.01 and log2 fold change threshold of ± 0.3, resulting in 131 upregulated and 20 downregulated proteins in SD patients. All statistical results are available in Additional file 2: Table S1 and Additional file 2: Table S2. *Ambiguous protein annotation; in such cases only the first protein was included in subsequent analyses