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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

Fig. 3

SHH nodules are uniquely characterized by deposits of sulphur-containing species and a collagen-based outer shell. a 3D OrbiSIMS mass spectrometry imaging identified several sulphur-containing species within the outer shell of ONS 76 nodules that are non-specifically distributed in HD-MB03 nodules. b Similar to the localization of sulphur species, collagens (Col I and Col VI) are specifically located at the outer surface of SHH (DAOY, ONS-76) nodules compared to nonspecific or no expression in Group 3 nodules (D458, HD-MB03). c Expression of COL6A1, COL6A2, COL6A3, COL1A1, COL1A2 and COL3A1 is significantly higher in SHH patients compared to Group 3 patients in the Cavalli data set (Cavalli et al. [21], SHH: n = 223 and Group 3: n = 144; Kruskal–Wallis test with Dunn’s post hoc test; ***P < 0.001)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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