Fig. 8

Hydrogen peroxide-induced Ctgf facilitates the effective migration of SCs to sustain axonal re-growth. A Magnification showing SC (GFP-positive, green) migration across the bridge upon sciatic nerve cut (five to seven days) in the absence (left panels) or presence (right panels) of an anti-Ctgf neutralizing antibody. Scale bars: 100 µm. B, C Intra-sciatic delivery of catalase slows down SC migration across the bridge in regenerating nerves (four days after crush). Scale bar: 100 µm. Axon density in the bridge was quantified by converting fluorescent images to black and white and measuring pixel density in the selected crush area (C). N = 3, *p = 0.031