Fig. 1

Tau-positive Pathology and Neurons in Aphasic Dementia. (a–d) Granule cell tau pathology visualized through AT8 immunohistochemical staining. (e–h) Hilar tau pathology revealed through AT8 immunohistochemical staining. (i–l) Granule neuronal density revealed through histochemical staining with cresyl violet. (a, e, i) was taken from case PiD 7, (b, f, j) was taken from CBD 6, (c, g, k) was taken from PSP 4, and (d, h, l) was taken from PPA-AD 3. PiD images show intense tau neuropathologic burden in both granule (a) and hilar (e) cells. CBD images show greater neuropathologic inclusions in granule cells (b), while PPA-AD has more inclusions in the hilar region (h). PSP shows uniformly sparse pathology (c, g). While PSP and AD show relatively preserved neuronal densities (k, l), there is no significant difference between neuronal densities across tauopathies. Scale bar = 50 µm in h, and applies to a–g. Scale bar = 100 µm in l, and applies to i–k