Fig. 6

Aβ deposits in AD-like degu brain are immunoreactive to the common Alzheimer’s pathologic molecular markers. Immunofluorescence confocal micrographs double-labeling of mOC23 with Aβ42 (a–c) or Aβ40 (d–f), Aβ43 with pyroglutamate Aβ (AβpE3) (g–i), and mOC23 with ubiquitin (Ub) (j–l) or AT8 (m–o) or PHF1 (p–r) for phosphorylate tau. Prominent signal indicated by arrows in panels from the two left columns are overlapped in the corresponding merged panels c, f,i, l, o, r from the right column. Merged images show green and red channel with DAPI that stains nuclei blue. Merge of red and green results in yellow (f, l, o), and overlap of red with blue yields magenta (c, f,i, l, o, r). The staining pattern of mOC23 with ubiquitin or phosphorylated tau (AT8 and PHF1) exhibit neurite-like structures that are similar to those detected by 6E10 in Fig. 3e, suggesting that these are similar to neuritic plaques