Fig. 5

Sex differences in αSyn-KO mice hippocampal LTP. A Field excitatory postsynaptic potentials (fEPSPs) were recorded at CA1 synapses by stimulating the Schaffer collaterals. B Top, Representative fEPSP traces before (black) and after a high-frequency stimulation (HFS) of the Schaffer collaterals recorded from male (blue) and female (pink) αSyn-KO mice. Bottom, fEPSPs recorded from hippocampal CA1 during long-term potentiation induced by HFS of Schaffer collaterals (100 Hz, 1 s) of αSyn-KO females (n = 12, pink) and males (n = 14, blue). Arrowhead indicates application of HFS. C, D fEPSP slopes 1 min (C) and 60 min (D) following HFS (post), relative to baseline established prior to HFS (pre), from female and male αSyn-KO mice. Data are expressed as mean ± SEM; ★P < 0.05 compared to pre-HFS within the same sex group, ☆P < 0.05 compared to mice to opposite sex