Fig. 1

Schematic representation of AD subtypes and Braak’s NFT staging. a The panel shows the predominant location of tau neurofibrillary tangles (NFT) in hippocampus and association cortex, across subtypes, as described in Murray et al. [7]. In the figure, location of tau NFT is represented as green ellipsoids and blue circles. In green, hippocampus (HIP). In blue, association cortex, including medial frontal gyrus (MFG), superior temporal gyrus (STG), and inferior parietal gyrus (IPG). b Spreading of tau NFT as postulated by Braak and Braak [10], including stages from I to VI, over time. In green, hippocampus; in blue, association cortex; in pink, transentorhinal cortex (and Cornu Amonis 1 region of the hippocampus in Stage II). Abbreviations: AD = Alzheimer’s disease