Fig. 1

Pathologic Findings in Ubiquitin-Positive Astrogliopathy. Ubiquitin-positive glial inclusions are most prominent in the basal ganglia (a), associated with GFAP-positive gliosis (b) and increased Iba-1-positive activated microglia (c). Ubiquitin-positive glial inclusions also affected cortex (d), and the Bergmann glial layer of the cerebellar cortex (e). Control cases with primary age-related tauopathy do not show ubiquitin-positive glial inclusions in the mesial temporal cortex (f) or associated with Bergmann gliosis over a chronic infarct in the cerebellum (g). Ubiquitin-positive glial inclusions are typically fine linear aggregates in glial processes (h) with scattered glia also showing dense aggregates in the cell body (i). Linear accumulation in the glial processes of the cerebellum is prominent in the Bergmann glial cell layer (j). Scale bars are 50 μm (g) and 20 μm (h-j). Scale bar in g applies to a-g