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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

Fig. 3

Cognitive impairment is associated with specific pathway changes in BA9. A Heatmap shows the protein expression differences between cognitively impaired (ALSci) and non-impaired (ALSnoci) groups. B KEGG pathway analysis visualises the most enriched pathways in these groups. Graph was plotted based on fold enrichment and gene counts/pathway (dot size), coloured based on -log10(FDR). C Heatmaps show the Top 10 up- and downregulated proteins in each group. D Top 10 ALSci-specific protein changes with the number of the up and down-regulated proteins. E Gene ontology analysis show the most enriched molecular function terms using ALSci-specific proteins. F Subsynaptic localization of the ALSci-specific protein changes, discovered by the SynGO database. Schematic figure was created by using BioRender.com

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Acta Neuropathologica Communications

ISSN: 2051-5960

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