Fig. 4

The distribution of index of dispersion (“IOD”) for LCM-isolated cells (n = 1542) according to A diagnoses (Alzheimer’s disease (“AD”), control), B brain regions (hippocampal subfields CA1 (“Hippocampal CA1”), hippocampal subfields CA3 (“Hippocampal CA3”), Entorhinal cortex, Cerebellum, Temporal cortex). For each brain region, we tested whether AD diagnosis was predictive of IOD using a linear mixed-effects (lme) model (see Methods). Individuals were added as a random factor. Across all tested brain regions, differences were only marginally significant (p = 0.069). C The distribution of IOD across individuals (n = 20). Box plots were ordered by the median. Y-axes illustrate the IOD values on the log10 scale