Fig. 8

Immunohistochemical assessment of p-tau pSer-202 (CP13) in the body of the corpus callosum, at 5 months post GW toxic exposure. a–d GW treatment alone had no effect overall on the accumulation of p-Tau CP13 in the body of the corpus callosum (Sham/V, 0.14 ± 0.001 vs Sham/GWI, 0.25 ± 0.003; P > 0.05) but a GW treatment effect was observed in the animals previously exposed to r-mTBI (r-mTBI/V 0.53 ± 0.13% vs r-mTBI/GWI, 0.96 ± 0.15%; P < 0.0001, P < 0.05, Two-Way ANOVA-followed by Tukey post hoc comparisons). A three-Way ANOVA analysis revealed no Sex but a Treatment and an Injury effect: Sex F_{(1, 28)} = 0.013 P < 0.90; Injury F_{(1, 28)} = 98.58 P < 0.0001; Treatment F_{(1, 28)} = 24.18 P < 0.0001. Data are presented as mean SEM; Data are presented as Whiskers: Min to Max. Show all points; symbol represents 1 mouse N = 4 per group per Sex)