Fig. 6

Age distribution and outcome of PFA_EPN, EZHIP-overexpressing and H3K27M-mutant of our cohort (n = 7) and cases from the literature with available methylation data (n = 2, cases #10 and #11). Median age for EPN_PFA, H3K27M-mutant of 6 years (1.4–12) versus 2.4 years for EPN_PFA, EZHIP-overexpressing (0.1–22.5). Statistical significance was calculated with Mann–Whitney test (median, *p value 0.0168, n = 98) (a). Kaplan–Meier survival estimates of EFS and OS: no significant difference between EPN_PFA, EZHIP-overexpressing (red, n = 89, median EFS 28 months, median OS 123 months) and H3K27M-mutant (orange, n = 9, median EFS 79 months, median OS not reached), log rank test, p value 0.67 and 0.41 respectively (b, c). DMG: diffuse midline gliomas; EPN: ependymomas; EFS: event-free survival; OS: overall survival; PF: posterior fossa