Fig. 6

α-synuclein (αSYN) oligomers in the hippocampus in patients with or without cognitive impairment. A αSYN-PLA staining images of PD patients with or without cognitive impairment. The upper two images are from patients with cognitive impairment and the lower image is from a patient without cognitive impairment. The left images are low-magnification images of the hippocampus, including the granule cell layer and CA2. The right images are high-magnification images of the pyramidal cells in the CA2. B Each pathological score in the CA1 and CA2 between patients with and without cognitive impairment. Black squares represent the scores of patients with cognitive impairment; white squares represent the scores of patients without cognitive impairment. Scale bars 100 µm in low-magnification images, 10 µm in high-magnification images. CA, cornus ammonis; CI, cognitive impairment; *P < 0.05