Fig. 8
From: Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
Mitochondrial assays show altered mitochondrial function in early affected regions. Functional mitochondrial assays across the putamen, parahippocampus, frontal cortex and parietal cortex for a Complex I, b Complex II, c Complex II/III and d Complex IV. All are normalised to citrate synthase levels and the ArcSin (ASIN) of data used for statistical analysis. Regions are colour-coded for severity of pathology present at that stage of disease as shown in key. Mann–Whitney U-tests were performed with * representing p < 0.03, ** representing p < 0.002, *** representing p < 0.0002 and **** representing p < 0.0001. Error bars represent SEM. Graphs and statistics were completed using GraphPad Prism v8