Fig. 4

Validation of increased mitochondrial proteins in PD cases using multiple reaction monitoring LC–MS/MS. Graphs highlighting differences in fold change as a ratio against internal standard a–n for multiple mitochondrial proteins in the parahippocampus, o metallothionein-2 across the putamen, parahippocampus, cingulate cortex and frontal cortex, and p mitochondrial 2-oxoglutarate malate carrier across the putamen, parahippocampus and cingulate cortex. Regions are colour-coded for severity of pathology present at that stage of disease as shown in key. T-tests were done for each pairing and statistically significant results at p < 0.05 are highlighted on the graphs. Graphs and statistics completed with GraphPad Prism v8