Fig. 1
From: Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
Case selection according to Braak staging system. a Diagram indicating the amount of Lewy body pathology in the regions used in the study according to Braak staging criteria. Severity of pathology at early-mid stage Braak 3/4 and late Braak stage 6 is highlighted by colours shown in reference to the key. Table indicates how many cases used for each region and disease group. b Panel of representative pathology images from a Braak stage 3/4 brain, highlighting the level of alpha-synuclein pathology in each region at this stage of disease at 20 × and 40 × magnification. Regions are labelled as follows: SN Substantia nigra; Cau Caudate; Put Putamen; Temp Temporal cortex; Para Parahippocampal gyrus; Cing Cingulate cortex; Fron Frontal cortex; Pari Parietal cortex. Black arrows show Lewy body presence and red arrows Lewy neurites. All scale bars represent 10 μm