Skip to main content

Table 1 Characterization and quantification of pTDP-43-immunopositive spinal cord motor neuron (MN) inclusions, as well as diffuse cytoplasmic pTDP-43 staining and nuclear pan TDP-43 immunoreactivity, in seven micron paraffin-embedded formalin-fixed tissue sections of the cervical and thoracic spinal cord from all post-mortem tissue cases

From: Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration

Case # Diagnostic group pTDP-43 morphology Quantification (%MNs)
Globular Skein-like Punctate Diffuse Incl./diff Nuclear
1 Age-matched control +++
2 Age-matched control NA NA NA NA NA NA
3 Age-matched control +++
4 Age-matched control + ++
5 Age-matched control +++
6 Age-matched control + +++
7 Age-matched control +++
8 Age-matched control ++
9 Age-matched control ++
10 Age-matched control + ++
11 fALS (SOD1, I113T) + +
12 fALS (SOD1, I113T) ++ +
13 fALS (SOD1, D101G) + +
14 fALS (C9ORF72, 30+positive) ++ +
15 fALS (unknown mutation) ++ +
16 fALS (C9ORF72, 30+positive) ++++ +
17 fALS (C9ORF72, 30+positive) +++ +
18 sALS +++ +
19 sALS ++++ +
20 sALS ++++ +
21 sALS ++ +
22 sALS NA NA NA NA NA NA
23 sALS +++ +
24 sALS ++++ +
25 sALS ++ +
26 sALS NA NA NA NA NA NA
  1. Fixed tissues were not available (NA) for some cases. The four morphologies of pTDP-43 pathology were noted as present (√) or absent (−), and the proportion of motor neurons exhibiting any of the four morphologies quantified. The proportion of motor neurons exhibiting nuclear pan TDP-43 immunostaining was also quantified. Quantification classifications;− = 0%, + =  > 0–25%, ++  = 26–50%, +++ = 51–75%, ++++ = 76–100%