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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: BDNF-dependent modulation of axonal transport is selectively impaired in ALS

Fig. 6

TrkB and p75NTR levels are comparable at the NMJ between tibialis anterior (TA) and soleus muscles, and are not altered in disease. NMJ immunostainings of A (i) TrkB and B (i) p75NTR receptors at the pre- and post-synaptic compartments as well as in terminal Schwann cells as identified by ii) Syn/TUJ1, iii) ⍺-BTX, and iv) S100 staining, respectively. The boxed area in A-Bi-v ‘ is enlarged in A-Bi-v“. Scale bars in v' = 10 µm, scale bars in v" = 5 µm. Immunostaining quantifications of: C TrkB (genotype p = 0.868, muscle p = 0.109, interaction p = 0.781); and D p75.NTR (genotype p = 0.091, muscle p = 0.108, interaction p = 0.603) (n = 6). Data were compared by two-way ANOVA and Holm-Šídák's multiple comparisons tests. Means ± SEM are plotted for all graphs. Black (P73) and grey (P94) circle borders indicate age-matched mice. See also Additional file 2: Fig. S6

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