Fig. 2

BDNF stimulation differentially impacts axonal transport of signalling endosomes in motor neurons innervating fast and slow muscles in wild-type mice. A Average and maximum endosome speeds upon intramuscular BDNF stimulation in motor axons innervating tibialis anterior (average: *p = 0.029; maximum: p = 0.281), B lateral gastrocnemius (average: *p = 0.017; maximum: p = 0.178), and C) soleus (average: p = 0.485; maximum: p = 0.937). D Time signalling endosomes paused upon BDNF stimulation in motor axons innervating tibialis anterior (*p = 0.014), E lateral gastrocnemius (**p = 0.009) and F soleus (p = 0.559). Data were assessed by Mann–Whitney U tests (n = 5–8). Means ± SEM are plotted for all graphs. The colour coding of individual datapoints is consistent within the muscle and treatment type and reflects the same animal. *p < 0.05, **p < 0.01. See also Additional file 2: Figs. S1 and Table S1