Table 1 Summary of papers by pathology category

Tau

31

Adams et al. [2], n = 86

Arena et al. [6], n = 22

Arena et al. [7], n = 14

Armstrong et al. [10], n = 11

Armstrong et al. [11], n = 8 

Armstrong et al. [12], n = 11

Armstrong et al. [13], n = 4

Cherry et al. [26], n = 48

Cherry et al. [27], n = 45

Cherry et al. [23], n = 41

Combs and Kanaan [28] n = 5

Dale et al. 30], n = 11

Geddes et al.  [36], n = 4

Goldstein et al. [37], n = 8

Hof et al. [40], n = 3

Hsu et al. [44], n = 14

Kanaan et al. [46], n = 9

Kaufman et al. 48], n = 27

Kondo et al. [50], n = 16

Lucke-Wold et al. [54], n = 2

Mann et al. [55], n = 4

McKee et al. [59], n = 9

McKee et al. [60], n = 68

McKenzie et al. [61], n = 5

Moszczynski et al. [66], n = 5

Puvenna et al. [74], n = 6

Roberts et al.  [75], n = 8

Roberts et al. [76] n = 20

Seo et al. [78], n = 6

Standring et al. [80], n = 251

Walt et al. [88], n = 9

Bielschowski stain [30, 59, 76]

Phospho-neurofilament medium (BF10 [30, 75])

Tau 210 kDa (RT97 [75])

Pan-tau (aa210-230) (TAU-5 [74])

Conformation dependent p-tau (Alz-50 [61], GT7 [7], GT38 [6, 7])

Tau C-terminus (A0024 [36])

PAD exposed p-tau (TNT1 [46], TNT2 [28])

oligomeric p-tau (TOC1 [46], T22 [66])

tau cleaved D421 (TauC3 [46])

Tau N-terminus (Tau13 [7, 28])

3R p-tau [7, 23]

4R p-tau [7, 23]

PPP3CA [78]

Phospho-tau pS199 [78]

Phospho-tau pS202/pT205 (AT8 [10,11,12,13, 23, 26, 27, 44, 48, 59, 60, 74, 78], CP-13 [6, 7, 74])

Phospho-tau pS212/pT214 (AT100 [7])

Phospho-tau pS262 [7]

Phospho-tau pS396/pS404 (PHF-1 [7, 59])

Phospho-tau pS396 [78]

Phospho-tau pS422 [46]

Phospho-tau pT175 [66]

Phospho-tau pT231 [66]

Beta-amyloid

6

Armstrong [8], n = 6

Armstrong [9], n = 6

Hof et al. [40], n = 3

Roberts et al. [76], n = 20

Standring et al. [80], n = 251

Stein et al. [84], n = 114

Beta-Amyloid 1–42 (4G8 [40, 80], 4D12 [76], AB5078P [8,9,10, 12, 84])

Beta-Amyloid 1–40 (AB5074P [84])

Thioflavin S stain [40]

TDP-43

4

Anderson et al. [5], n = 18

King et al. [49], n = 3

McKee et al. [59], n = 9

McKee et al. [60] n = 68

Pan TDP-43 [49, 59, 60]

Phospho-TDP-43 [5, 49]

Lewy body

4

Adams et al. [2], n = 86

Kaufman et al. [48], n = 27

Mann et al. [55], n = 4

McKee et al. [60], n = 68

Alpha-synuclein [2, 48, 55, 60]

Astrogliosis

4

Chancellor et al. [21], n = 8

Cherry et al. [26], n = 48

Cherry et al. [27], n = 45

Hsu et al. [44], n = 14

GFAP [21, 26, 44]

CD44 [21]

NQO1 [27]

Microgliosis

3

Cherry et al. [25] n = 46

Cherry et al. [26], n = 48

Goldstein et al. [37], n = 8

HLA-DR [37]

Iba1 [25, 26]

CD68 [26]

TMEM119 [25]

Axonopathy

5

Bi et al. [15], n = 5

Chancellor et al. [21], n = 8

Goldstein et al. [37], n = 8

McKee et al. [60], n = 68

Warling et al. [89], n = 11

Phospho-neurofilament heavy [37, 60]

βIII tubulin [15]

Myelin-associated glycoprotein [15]

Olig2 [21]

Golgi stain [89]

Vascular dysfunction

3

Adams and Bruton [1], n = 18

Buée et al. [19], n = 2

Standring et al. [80], n = 251

Beta-amyloid [80]

Perivascular iron deposition [1]

Heparan sulfate proteoglycan [19]

Cell stress

3

Anderson et al. n = 18

Dale et al. [30] n = 11

Lucke-Wold et al. [54], n = 2

XBP1 [54]

phospho-eIF2a [54]

ATF6 [54]

CHOP [54]

Ubiquitin [30]

NUP62 [5]