Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology

Table 2 PET SUVR and stereological density per region of interest and corresponding laterality index and neocortical-to-entorhinal index

ROI	Hemisphere/Laterality	Florbetapir PVC SUVR	Thioflavin-S AP density mm³	Flortaucipir PVC SUVR	PHF-1 NFT density mm³
Entorhinal	L	0.95	2,086	1.29	3,745
	R	1.02	4,264	1.18	2,640
	Laterality index	− 7	− 69	+ 9	+ 35
Middle Frontal	L	2.48	8,784	2.99	50,668
	R	1.98	7,386	1.87	28,474
	Laterality index	+ 22	+ 17	+ 46	+ 56
Superior Temporal	L	2.23	9,005	3.00	37,741
	R	2.19	6,375	2.88	17,540
	Laterality index	+ 2	+ 34	+ 4	+ 73
Middle Temporal	L	1.69	6643	2.60	18,320
	R	1.54	4634	1.81	11,952
	Laterality index	+ 9	+ 36	+ 36	+ 42
Neocortical-to-entorhinal index		Not computed	Not computed	+ 68	+ 158

The left (L) and right (R) hemisphere stereological density estimations and PET measurements by region of interest (ROI). PET measures have been partial volume corrected (PVC) and referenced by whole cerebellum (florbetapir) or inferior cerebellar grey (flortaucipir) to create a standard uptake value ratio (SUVR). Stereological counts are either amyloid plaque (AP) or neurofibrillary tangle (NFT) densities. The calculation for the laterality index and neocortical-to-entorhinal index are outlined in the Methods. Briefly, a positive laterality index indicates L > R uptake or density, while a positive neocortical-to-entorhinal index indicates greater uptake or density in the six lateral cortical ROIs compared to the two entorhinal ROIs

ISSN: 2051-5960