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Table 4 Associations of mitochondrial DNA haplogroups with cortical Lewy body counts

From: Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Mitochondrial DNA Haplogroup Haplogroup frequency, No. (%),
N = 242
Association with middle frontal LB count Association with superior temporal LB count Association with inferior parietal LB count Association with cingulate LB count Association with parahippocampal LB count
Multiplicative effect (95% CI) P−value Multiplicative effect (95% CI) P−value Multiplicative effect (95% CI) P-value Multiplicative effect (95% CI) P-value Multiplicative effect (95% CI) P-value
Na 0 (0.0%)
N1a 0 (0.0%)
Ia 8 (3.3%)
Wa 2 (0.8%)
Xa 4 (1.7%)
R and R0a 1 (0.4%)
HV and HV0aa 8 (3.3%)
H, H1, H2, H3 and H4 91 (37.6%) 1.16 (0.95, 1.43) 0.15 1.05 (0.89, 1.25) 0.56 1.12 (0.91, 1.39) 0.28 1.06 (0.92, 1.22) 0.41 1.02 (0.88, 1.18) 0.83
H 40 (16.5%) 1.01 (0.77, 1.34) 0.93 0.93 (0.74, 1.18) 0.57 0.89 (0.67, 1.18) 0.41 0.94 (0.78, 1.14) 0.54 0.96 (0.80, 1.17) 0.70
H1 27 (11.2%) 1.10 (0.80, 1.52) 0.57 0.94 (0.72, 1.24) 0.64 1.08 (0.78, 1.50) 0.64 1.00 (0.80, 1.25) 0.98 0.90 (0.72, 1.13) 0.34
H2a 8 (3.3%)
H3 12 (5.0%) 1.03 (0.66, 1.65) 0.91 1.18 (0.82, 1.75) 0.38 1.22 (0.78, 1.94) 0.40 1.10 (0.82, 1.51) 0.52 1.03 (0.76, 1.42) 0.84
H4a 4 (1.7%)
Va 8 (3.3%)
JTa 0 (0.0%)
J, J1, J1d, J2a and J2b 26 (10.7%) 0.92 (0.67, 1.30) 0.64 0.99 (0.76, 1.31) 0.94 1.13 (0.81, 1.58) 0.48 0.99 (0.79, 1.25) 0.92 1.02 (0.81, 1.31) 0.85
Ja 0 (0.0%)
J1 23 (9.5%) 0.87 (0.61, 1.25) 0.44 0.96 (0.72, 1.29) 0.77 1.02 (0.71, 1.47) 0.92 0.97 (0.76, 1.24) 0.79 1.03 (0.81, 1.34) 0.80
J1da 0 (0.0%)
J2aa 2 (0.8%)
J2ba 1 (0.4%)
T, T1 and T2 30 (12.4%) 1.05 (0.78, 1.43) 0.75 0.81 (0.63, 1.06) 0.11 0.88 (0.64, 1.21) 0.42 0.95 (0.77, 1.16) 0.59 0.91 (0.74, 1.12) 0.37
Ta 0 (0.0%)
T1a 4 (1.7%)
T2 26 (10.7%) 1.03 (0.75, 1.43) 0.86 0.76 (0.58, 1.00) 0.044 0.79 (0.57, 1.12) 0.18 0.93 (0.75, 1.16) 0.50 0.90 (0.72, 1.13) 0.34
U, U1, U3, U5, U6 and U8b'c 41 (16.9%) 0.84 (0.64, 1.10) 0.20 1.02 (0.82, 1.28) 0.85 0.91 (0.69, 1.20) 0.49 0.97 (0.81, 1.16) 0.70 0.97 (0.80, 1.18) 0.75
U 12 (5.0%) 0.94 (0.60, 1.52) 0.79 1.16 (0.80, 1.71) 0.45 0.95 (0.59, 1.55) 0.82 1.11 (0.82, 1.52) 0.49
U1a 2 (0.8%)
U3a 1 (0.4%)
U5 25 (10.3%) 0.82 (0.59, 1.15) 0.23 0.95 (0.72, 1.25) 0.69 0.95 (0.68, 1.33) 0.74 0.91 (0.73, 1.14) 0.40 0.92 (0.72, 1.18) 0.50
U6a 0 (0.0%)
U8b'ca 1 (0.4%)
K 23 (9.5%) 1.15 (0.82, 1.64) 0.43 1.17 (0.88, 1.57) 0.30 1.10 (0.77, 1.59) 0.60 1.06 (0.84, 1.35) 0.64 1.13 (0.87, 1.48) 0.36
  1. Multiplicative effects, 95% CIs, and p-values result from negative binomial regression models that were adjusted for age at death and sex. Multiplicative effects are interpreted as the multiplicative increase on the mean LB count for the given haplogroup. After applying a Bonferroni correction for multiple testing separately for each outcome measure, P-values < 0.0042 (associations with middle frontal, superior temporal, inferior parietal, and cingulate LB counts) and < 0.0045 (associations with parahippocampal LB count) were considered statistically significant.
  2. aHaplogroups that occurred in < 10 subjects in a given association analysis not examined in that analysis. LB = Lewy body. CI = confidence interval