Table 4 Associations of mitochondrial DNA haplogroups with cortical Lewy body counts
Mitochondrial DNA Haplogroup | Haplogroup frequency, No. (%), N = 242 | Association with middle frontal LB count | Association with superior temporal LB count | Association with inferior parietal LB count | Association with cingulate LB count | Association with parahippocampal LB count | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Multiplicative effect (95% CI) | P−value | Multiplicative effect (95% CI) | P−value | Multiplicative effect (95% CI) | P-value | Multiplicative effect (95% CI) | P-value | Multiplicative effect (95% CI) | P-value | ||
Na | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
N1a | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
Ia | 8 (3.3%) | – | – | – | – | – | – | – | – | – | – |
Wa | 2 (0.8%) | – | – | – | – | – | – | – | – | – | – |
Xa | 4 (1.7%) | – | – | – | – | – | – | – | – | – | – |
R and R0a | 1 (0.4%) | – | – | – | – | – | – | – | – | – | – |
HV and HV0aa | 8 (3.3%) | – | – | – | – | – | – | – | – | – | – |
H, H1, H2, H3 and H4 | 91 (37.6%) | 1.16 (0.95, 1.43) | 0.15 | 1.05 (0.89, 1.25) | 0.56 | 1.12 (0.91, 1.39) | 0.28 | 1.06 (0.92, 1.22) | 0.41 | 1.02 (0.88, 1.18) | 0.83 |
H | 40 (16.5%) | 1.01 (0.77, 1.34) | 0.93 | 0.93 (0.74, 1.18) | 0.57 | 0.89 (0.67, 1.18) | 0.41 | 0.94 (0.78, 1.14) | 0.54 | 0.96 (0.80, 1.17) | 0.70 |
H1 | 27 (11.2%) | 1.10 (0.80, 1.52) | 0.57 | 0.94 (0.72, 1.24) | 0.64 | 1.08 (0.78, 1.50) | 0.64 | 1.00 (0.80, 1.25) | 0.98 | 0.90 (0.72, 1.13) | 0.34 |
H2a | 8 (3.3%) | – | – | – | – | – | – | – | – | – | – |
H3 | 12 (5.0%) | 1.03 (0.66, 1.65) | 0.91 | 1.18 (0.82, 1.75) | 0.38 | 1.22 (0.78, 1.94) | 0.40 | 1.10 (0.82, 1.51) | 0.52 | 1.03 (0.76, 1.42) | 0.84 |
H4a | 4 (1.7%) | – | – | – | – | – | – | – | – | – | – |
Va | 8 (3.3%) | – | – | – | – | – | – | – | – | – | – |
JTa | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
J, J1, J1d, J2a and J2b | 26 (10.7%) | 0.92 (0.67, 1.30) | 0.64 | 0.99 (0.76, 1.31) | 0.94 | 1.13 (0.81, 1.58) | 0.48 | 0.99 (0.79, 1.25) | 0.92 | 1.02 (0.81, 1.31) | 0.85 |
Ja | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
J1 | 23 (9.5%) | 0.87 (0.61, 1.25) | 0.44 | 0.96 (0.72, 1.29) | 0.77 | 1.02 (0.71, 1.47) | 0.92 | 0.97 (0.76, 1.24) | 0.79 | 1.03 (0.81, 1.34) | 0.80 |
J1da | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
J2aa | 2 (0.8%) | – | – | – | – | – | – | – | – | – | – |
J2ba | 1 (0.4%) | – | – | – | – | – | – | – | – | – | – |
T, T1 and T2 | 30 (12.4%) | 1.05 (0.78, 1.43) | 0.75 | 0.81 (0.63, 1.06) | 0.11 | 0.88 (0.64, 1.21) | 0.42 | 0.95 (0.77, 1.16) | 0.59 | 0.91 (0.74, 1.12) | 0.37 |
Ta | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
T1a | 4 (1.7%) | – | – | – | – | – | – | – | – | – | – |
T2 | 26 (10.7%) | 1.03 (0.75, 1.43) | 0.86 | 0.76 (0.58, 1.00) | 0.044 | 0.79 (0.57, 1.12) | 0.18 | 0.93 (0.75, 1.16) | 0.50 | 0.90 (0.72, 1.13) | 0.34 |
U, U1, U3, U5, U6 and U8b'c | 41 (16.9%) | 0.84 (0.64, 1.10) | 0.20 | 1.02 (0.82, 1.28) | 0.85 | 0.91 (0.69, 1.20) | 0.49 | 0.97 (0.81, 1.16) | 0.70 | 0.97 (0.80, 1.18) | 0.75 |
U | 12 (5.0%) | 0.94 (0.60, 1.52) | 0.79 | 1.16 (0.80, 1.71) | 0.45 | 0.95 (0.59, 1.55) | 0.82 | 1.11 (0.82, 1.52) | 0.49 | – | – |
U1a | 2 (0.8%) | – | – | – | – | – | – | – | – | – | – |
U3a | 1 (0.4%) | – | – | – | – | – | – | – | – | – | – |
U5 | 25 (10.3%) | 0.82 (0.59, 1.15) | 0.23 | 0.95 (0.72, 1.25) | 0.69 | 0.95 (0.68, 1.33) | 0.74 | 0.91 (0.73, 1.14) | 0.40 | 0.92 (0.72, 1.18) | 0.50 |
U6a | 0 (0.0%) | – | – | – | – | – | – | – | – | – | – |
U8b'ca | 1 (0.4%) | – | – | – | – | – | – | – | – | – | – |
K | 23 (9.5%) | 1.15 (0.82, 1.64) | 0.43 | 1.17 (0.88, 1.57) | 0.30 | 1.10 (0.77, 1.59) | 0.60 | 1.06 (0.84, 1.35) | 0.64 | 1.13 (0.87, 1.48) | 0.36 |