Fig. 1

Neuropathological and genetic findings in DIA. Heterogeneous and cystic tumor in a cranial scan (A). A well-delineated tumor in the postmortem examination (B). Histopathological pattern of DIA: general features (C), atypical astrocytes with a gemistocytic pattern (hematoxylin and eosin stain) (D), GFAP-positive neoplastic cells (E), desmoplastic stroma in Gomori samples (F) and low proliferative index (G). Histopathological aggressive pattern in DIA: general features (H), morphological atypical cells with mitosis (I), necrosis with perinecrotic palisading neoplastic cells (J), vascular hyperplasia and microthrombosis (K), CD34-positive expression in microvascular structures (L), GFAP-positive neoplastic cells in perinecrotic areas (M), high proliferative index (N), area with a small-cell population which express CD133 protein (O), that alters the reticulin (P) and vessel distribution (Q). Molecular alterations: BRAF V600E mutation (R) and PTEN deletion in MLPA analysis (S)