Table 2 Demographic, clinical, and post-mortem characteristics for cortical frontal and temporal samples from the independent validation cohort

Demographics

Female, n (%)

2/2 (100.0)

0/3 (0.0)

Age, median (range)

63.5 (61–66)

57.0 (55–65)

Clinical characteristics

Genetic mutation (n)

S82fs (1)

A886G (1)

c.1179 + 104_1536delinsCTGA (1)

P301L (2)

Disease pathology (n)

• Atypical Pick’s disease

–

1

• Tau

–

2

• TDP-type A

2

–

Post-Mortem determinants

Post-mortem delay, median (range)

08:05 (05:19–10:50)

05:15 (04:25–05:40)

Cerebrospinal fluid pH, median (range)

6.23 (6.22–6.24)

6.36 (6.35–6.37)

Brain weight in grams, median (range)

1027 (1002–1052)

1197 (1100–1395)

Braak score, median (range)

1 (n/a)

0 (0–0)