Fig. 6
From: Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10
CHCHD10WT rescues impaired synaptic plasticity in TDP-43 transgenic mice (TAR4). a Representative brain section images from 10-month-old TAR4 and TAR4;D10WT mice immunostained for synaptophysin (green). Small white boxes magnified in larger upper right insets. b Quantification of synaptophysin intensity in hippocampus CA3 region from Fig. (6a) (1-way ANOVA – synaptophysin: F(2, 63) = 23.07, P < 0.0001; posthoc Tukey, **p < 0.01, #p < 0.001, ##p < 0.0001, n = 20–27 section/genotype from 4 mice/genotype). c-d Brain slices from 10-month-old TAR4 and TAR4;D10WT mice subjected to (c) PPF from 20 to 300 ms interstimulus intervals (2-way ANOVA, genotype F(2, 1815) = 7.891, P = 0.0004: posthoc Tukey, not significant, n = 24–58 slices from 3–5 mice/genotype) and (d) LTP induced by theta burst stimulation (2-way ANOVA, genotype F(2, 8640) = 991.0, P < 0.0001: posthoc Tukey, ##p < 0.0001, n = 24–51 slices/genotype from 3–5 mice/genotype)