Table 4 Characteristics of subsample for examination of glial cells in A\(\upbeta\) plaque microenvironment, and comparison of glial cell areas between HIV-negative, HIV-undetectable, and HIV-detectable age-matched groups

n

31

12

11

8

Mean age (SEM)

61.7 (1.28)

61.7 (2.10)

62.8 (2.19)

60.1 (2.57)

Male gender, n (%)^a

15 (48%)

7 (58%)

2 (18%)

6 (75%)

APOE \(\upvarepsilon\)4, n (%)^b

16 (52%)

3 (25%)

6 (55%)

7 (88%)

APOE \(\upvarepsilon\)2, n (%)

3 (9.7%)

2 (17%)

0

1 (13%)

Mean area diffuse plaque, um² (SEM)

2495 (310)

2213 (503)

2350 (526)

3115 (617)

Mean area cored plaque, um² (SEM)*

1560 (94)

1548 (159)

1649 (159)

1445 (194)

cored plaques

GFAP plaque

0.7174 [0.1098,1.2907]

0.1126 [0.0305,1.2316]

1.0813 [0.6481,1.2491]

0.2959 [0.0000,1.4296]

GFAP rim

0.4148 [0.0736,0.9678]

0.0885 [0.0239,0.9515]

0.6775 [0.4148,0.9360]

0.2008 [0.0268,1.0748]

CD68 plaque

0.7098 [0.1445,1.0210]

0.8035 [0.0993,1.0601]

0.8004 [0.3006,1.0100]

0.4198 [0.1282,1.2166]

CD68 rim

0.1570 [0.6844,0.1780]

0.1632 [0.0649,0.1964]

0.1313 [0.0797,0.1766]

0.1146 [0.0494,0.2480]

Iba1 plaque

0.9427 (0.0810)

0.9651 (0.1383)

0.9425 (0.1383)

0.9093 (0.1694)

Iba1 rim

0.5612 (0.0504)

0.6003 (0.0845)

0.5761 (0.0845)

0.4800 (0.1034)

diffuse plaques

GFAP plaque

0.4327 [0.0592,0.8564]

0.1513 [0.0394,0.9381]

0.6198 [0.0969,0.7264]

0.3205 [0.1084,0.8807]

GFAP rim

0.3135 [0.0558,0.6165]

0.1392 [0.0509,0.6278]

0.4609 [0.0781,0.6165]

0.3612 [0.0763,0.7271]

CD68 plaque

0.1682 [0.0931,0.3177]

0.1478 [0.1027,0.2158]

0.1970 [0.0641,0.3547]

0.2592 [0.0664,0.3815]

CD68 rim

0.1492 [0.1099,0.1673]

0.1444 [0.1097,0.1937]

0.1489 [0.1086,0.1673]

0.1576 [0.1257,0.2428]

Iba1 plaque

0.7593 (0.0602)

0.7855 (0.0994)

0.7077 (0.1038)

0.7906 (0.1217)

Iba1 rim

0.5970 (0.0452)

0.6353 (0.0745)

0.5556 (0.0779)

0.5965 (0.0913)