Fig. 1

Diagnostically and clinically useful DNA methylation report with an indeterminate score. A hematoxylin and eosin stained section of a glioblastoma with about 50% cellularity (a). Classified by DNA methylation as a glioblastoma subclass mesenchymal with an indeterminate score of 0.569. T-SNE shows this case clustering closely with glioblastoma, subclass mesenchymal in green (b). The copy number plot generated from the DNA methylation data shows an EGFR amplification, consistent with the diagnosis of glioblastoma, as well as MDM4, MDM2, and CDK4 amplifications (c)