Fig. 4

Bivariate regression plots showing correlations between CAG repeat expansion and neocortical HTT/ p62 inclusion density. a HTT inclusion density correlates with CAG repeat expansion and increasing gradient of HTT burden along a caudal to rostral direction. b The x-intercepts of the extrapolated linear regression lines between HTT and CAG imply that inclusions may be formed in individuals with intermediate CAG expansion. c p62 inclusion density significantly correlates with CAG repeat expansion in BA17, BA7 and BA9