Table 3 Status of NMJs analyzed by confocal microscopy per donor biopsy
From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Donor ID and disease status | Fully Innervated (%) of total NMJs/Donor | Partially denervated-reinnervated (%) of total NMJs/Donor | Denervated (%) of total NMJs/Donor |
|---|---|---|---|
Con-1 | 2/2 NMJs (100%) | 0/2 NMJs | 0/2 |
Con-2 | 12/12 NMJs (100%) | 0/12 NMJs | 0/12 |
Con-3 | 17/19 NMJs (89%) | 2/19 NMJs (11%) | 0/19 |
Con-4 | 20/22NMJs (90%) | 2/22 NMJs (10%) | Â |
Con-5 | 10/12 NMJs (83%) | 2/12 NMJs (17%) | 0/12 |
Con NMJ Mean % | 92.4% | 7.6% | 0% |
MND-2 | 4/13 NMJs (30%) | 9/13 NMJs (70%) | 0/13 NMJs |
MND-3 | 5/40 (12%) | 20/40 (50%) | 15/40 NMJs (38%) |
MND-4 | 0/24 (0%) | 20/24 (83%) | 4/24 (17%) |
MND NMJ Mean % | 14% | 67% | 18% |