From: Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
Donor IDs | Sex | Age | Diagnosis | Site of onset | ALSFRS-R (at biopsy) | Interval—Symptom Onset to Biopsy months | No NMJs imaged | Muscle pathology |
---|---|---|---|---|---|---|---|---|
Con-3# | M | 44 | Â | Â | Â | Â | 19$ | Normal |
Con-4 | M | 54 | Â | Â | Â | Â | 22$, 7* | Inclusion Body Myositis |
Con-5 | M | 39 | Â | Â | Â | Â | 12$ | Focal Denervation |
MND-1^ | M | 57 | Sporadic MND | Spinal | 34 | 10 | 4* | Chronic progressive denervation, early fiber type grouping |
MND-3^ | F | 56 | Sporadic MND | Spinal | N/A | 10 | 40$, 5* | Chronic progressive denervation, early fiber type grouping |
MND-4 | M | 61 | Sporadic MND | Spinal | 41 | 60 | 24$ | Chronic denervation; collateral reinnervation, fiber type grouping |
MND-5 | M | 63 | Sporadic MND | Spinal | 40 | 31 | 2* | Chronic progressive denervation, fiber type grouping |
MND-6 | F | 77 | Sporadic MND | Bulbar | 29 | 31 | 3* | Chronic progressive denervation, fiber type grouping |
MND-7^ | F | 68 | Sporadic MND | Spinal | 40 | 12 | Â | Denervation atrophy, early fiber type grouping |