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Table 2 Performance of each tau antibody in consensus reporting of CTE-NC as absent or present

From: Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change

  AUC (95% CI) Sensitivity % Specificity % PPV % NPV %
All sections 0.74
(0.70–0.77)
57.9 86.1 92.6 40.5
PHF-1 0.85
(0.79–0.92)
80.6 86.1 94.6 59.6
4R 0.82
(0.74–0.89)
73.0 83.0 92.9 50.8
GT-38 0.75
(0.70–0.80)
51.9 97.2 98.2 40.2
3R 0.52
(0.46–0.59)
15.7 88.9 81.0 26.0
  1. AUC = area under the curve; PPV = positive predictive value; NPV = negative predictive value; GT38 vs. 4R, p = 0.140; GT38 vs. PHF-1, p < 0.005; 4R vs. PHF-1, p = 0.375; 3R vs. PHF-1, p < 0.001