Fig. 5
From: Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
Reduced Igf-1r activation but invariant TrkB activation in the hippocampus of exercising 3-month-old Bp5 tg + mice. a–d Igf-1r and e–h TrkB immunoprecipitation from hippocampal and cortical lysates of 3- and 18-month-old wild-type and Bp5 tg + mice either sedentary or voluntarily running for 7 days. Data represent mean ± SD, ANOVA, Kruskal–Wallis test, Dunn’s post hoc test, *p < 0.05; n = number of mice. Values were normalized to 3-month-old WTSed hippocampus (a, e) or anterior cortex (b, f) or to 18-month-old WTSed hippocampus (c, g) or anterior cortex (d, h), UBF unbound fraction, IP immunoprecipitation